Cytologic Features of Metastatic Sebaceous Carcinoma: Report of Two Cases With Comparison to Three Cases of Basal Cell Carcinoma

1999 ◽  
Vol 21 (5) ◽  
pp. 340-345 ◽  
Author(s):  
Saha Sadeghi ◽  
Martha B. Pitman ◽  
Michele M. Weir
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Sebaceous Carcinoma

Coexistence of Low-grade Sebaceous Carcinoma and Basal Cell Carcinoma in a Nevus Sebaceus

2011 ◽  
Vol 73 (2) ◽  
pp. 152-156
Author(s):  
Mio MACHIDA ◽  
Yasutoshi HIDA ◽  
Yoshiaki KUBO ◽  
Seiji ARASE ◽  
Shin-ichi ANSAI
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Sebaceous Carcinoma ◽  
Low Grade ◽  
Nevus Sebaceus

scholarly journals Optical Coherence Tomography of Peri-Ocular Skin Cancers: An Optical Biopsy

2020 ◽  
pp. 1-9
Author(s):  
Sabrina Bergeron ◽  
Bryan Arthurs ◽  
Debra-Meghan Sanft ◽  
Christina Mastromonaco ◽  
Miguel N. Burnier Jr.
Keyword(s):  
Squamous Cell Carcinoma ◽  
Optical Coherence Tomography ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Basal Cell ◽  
Skin Lesions ◽  
Sebaceous Carcinoma ◽  
Optical Coherence ◽  
Oct Imaging

<b><i>Introduction:</i></b> Optical coherence tomography (OCT) imaging has been used as a diagnostic tool for retinal disease for several years, and OCT apparatuses are becoming increasingly powerful. However, OCT has yet to reach its full potential in ophthalmology clinics. Alike retinal layers, it has been shown that OCT is able to generate cross-sectional images of the skin and allows visualization of skin lesions in a histopathology-like manner. <b><i>Objective:</i></b> We aim to validate OCT as an imaging modality for peri-ocular skin cancer. Through a series of cases, we highlight findings for 3 common eyelid malignancies: basal cell carcinoma, squamous cell carcinoma and sebaceous carcinoma. We propose an OCT image-based signature for basal cell carcinoma. <b><i>Methods:</i></b> This is a prospective study. Fifty-eight lesions suspicious of malignancy from 57 patients were subjected to OCT imaging prior to the surgical excision of the lesion. OCT images were analysed and scored according to previously identified OCT features. Eight representative examples are presented, highlighting the OCT patterns for each malignancy side by side to its corresponding histopathological sections. <b><i>Results:</i></b> Out of the 58 lesions analysed, 53 were malignant. A loss of the dermal-epidermal junction is observed in all malignant lesions. A strong link is observed between the presence of subepithelial hyporeflective nests on OCT and the diagnosis of basal cell carcinoma (present in 83% of cases). Conversely, lesions of epithelial origin such as squamous cell carcinoma are most often represented on OCT by acanthosis. Two supplementary cases, one basal cell carcinoma and one sebaceous carcinoma, are provided to illustrate how OCT imaging is a valuable tool in cases where clinical observations may be unusual. <b><i>Conclusions:</i></b> We provide evidence supporting the use of OCT for the evaluation of peri-ocular cancers. OCT enables visualization of the skin layers in vivo, before biopsy. Our results show that certain OCT features can contribute to include or exclude a diagnosis of basal cell carcinoma. By integrating this non-invasive imaging methodology into the routine assessment of peri-ocular skin lesions, especially in health care centres where access to specialists is limited, OCT imaging can increase clinical precision, reduce delays in patient referral and enhance patient care.

Sebaceous carcinoma and basal cell carcinoma arising within nevus sebaceous on the face—A rare entity with dermatoscopic findings

2020 ◽  
Vol 33 (4) ◽  
Author(s):  
Seher Bostanci ◽  
Bengu Nisa Akay ◽  
Cengizhan Erdem ◽  
Aylin Okcu Heper ◽  
Banu Farabi
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Sebaceous Carcinoma ◽  
Rare Entity ◽  
The Face ◽  
Nevus Sebaceous

A case of extraocular sebaceous carcinoma with basal cell carcinoma-like structures

Skin Cancer ◽  
2011 ◽  
Vol 26 (2) ◽  
pp. 170-173
Author(s):  
Takeshi NAMIKI ◽  
Keiko MIURA ◽  
Eishi TAKAHASHI ◽  
Kouhei KATO ◽  
Aya NISHIZAWA ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Sebaceous Carcinoma

scholarly journals Histologic Mimics of Basal Cell Carcinoma

2017 ◽  
Vol 141 (11) ◽  
pp. 1490-1502 ◽  
Author(s):  
Lauren M. Stanoszek ◽  
Grace Y. Wang ◽  
Paul W. Harms
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Malignant Tumors ◽  
Malignant Neoplasm ◽  
Sebaceous Carcinoma ◽  
Current Evidence ◽  
Ancillary Data ◽  
Immunohistochemical Markers ◽  
Follicular Tumors

Context.— Basal cell carcinoma (BCC) is the most common human malignant neoplasm and is a frequently encountered diagnosis in dermatopathology. Although BCC may be locally destructive, it rarely metastasizes. Many diagnostic entities display morphologic and immunophenotypic overlap with BCC, including nonneoplastic processes, such as follicular induction over dermatofibroma; benign follicular tumors, such as trichoblastoma, trichoepithelioma, or basaloid follicular hamartoma; and malignant tumors, such as sebaceous carcinoma or Merkel cell carcinoma. Thus, misdiagnosis has significant potential to result in overtreatment or undertreatment. Objective.— To review key features distinguishing BCC from histologic mimics, including current evidence regarding immunohistochemical markers useful for that distinction. Data Sources.— Review of pertinent literature on BCC immunohistochemistry and differential diagnosis. Conclusions.— In most cases, BCC can be reliably diagnosed by histopathologic features. Immunohistochemistry may provide useful ancillary data in certain cases. Awareness of potential mimics is critical to avoid misdiagnosis and resulting inappropriate management.

scholarly journals Study of histomorphological spectrum of eyelid lesions

2021 ◽  
Vol 11 (1) ◽  
pp. 1790-1802
Author(s):  
Reshmi Shrestha ◽  
Gita Sayami
Keyword(s):  
Squamous Cell Carcinoma ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Basal Cell ◽  
Sebaceous Carcinoma ◽  
Epidermal Cyst ◽  
Wide Range ◽  
Malignant Lesions ◽  
Eyelid Lesions

Background: Eyelid pathologies are the most common surgical specimens encountered among all of the ophthalmic lesions and constitute a wide range of diseases by their unique histologic features. This study aims to find out the histopathological spectrum of eyelid lesions, their demographic distribution, and preferential location prevalent in our community.Materials and Methods: This is an observational study in which we retrospectively evaluated the data of 692 patients retrieved from the histopathology department of National Reference Laboratory, Kathmandu, from May 2016 to April 2019.Results: A total of 701 histologic diagnoses comprised of benign, precursor, and malignant lesions and accounted for 86.6%, 2.6%, and 10.8% respectively with preponderance in females. The common benign lesions included melanocytic nevus (17.7%), epidermal cyst (11%), hemangioma (8.9%), dermoid cyst (8.2%), chalazion (6.7%), and squamous papilloma (6.4%). Tumour of epidermal origin was the most common neoplastic lesion accounting for 31.2%. Basal cell carcinoma (50%) followed by sebaceous carcinoma (27.6%) and squamous cell carcinoma (14.5%) constituted the majority of malignant lesions prevalent above the age of 60 years with the preferential site of the upper eyelid for basal cell carcinoma and squamous cell carcinoma; and lower eyelid for sebaceous carcinoma.Conclusions: Benign eyelid lesions are more prevalent than malignant ones with overall female  preponderance. Epidermal tumours are common among neoplasms. A malignant tumour, a disease of  an elderly individual, is predominated by basal cell carcinoma followed by sebaceous carcinoma, an aggressive tumour with a high recurrence rate in our population.

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